DISCLAIMER :

 

This section only summarizes the theoretical path of synthesis (without details/detailed instructions of the requirment for a successful reaction run. Experimental detailed details are omitted due to safety concern and legal reasons ) of some certain compounds which are subject to research and development and educational purpose only for individuals and government authoritys. Lets make any field knowladgebase available to all. (Hidding any knowladge in any field from others may strongly be related to paranoid delusional disorder of individual ( for which he already realise that its stands on fragile foundations ) again and again related to mAChRs issues with consequently cognitive decline. ) Any unskilled attempt ( from a safe or technological point of view ) to synthesize any compounds in this theoretical compound thread without prior calculation and consideration of the reaction conditions or safety precautions can lead to explosion, fire, death , permanent or temporary CNS damage , paralysis or other physical damage to themselves and others in the surroundings area, and most of them are hazardous to the environment. 

 

 

 

23.04.2025 12:14

w/ more greener route ; coupling reaction using :

TCDI reagent 

TBDMSCl (for alcohol protection)(optional)

3-(dimethylamino)benzene-1-thiol = (3-Aminophenol + formaldehyde + STAB or Formic acid Eschweiler–Clarke reaction or Me2SO4) + (Lawesson reagent for 3-(dimethylamino)benzene-1-thiol)

Dimethylamine HCl or freebase 2M in THF

triethylamine(base)

CH3I or CH3Br or CH3Cl

Sodium tetrafluoroborate

Reagents/reactants needed :

CDI

TCDI

HMDS (ammonolysis for amidation) (or Ammonia hydroxide (aq.) NH4OH)  

Hydrazine hydrate

1,3-adamantanedimethanol

 

 

 

19.04.2025 15:49

Directly from R'COOH  w/  :

 

1. Deep Eutectic Solvents (DES)

or

2. Coupling Reaction (EDC.HCl or CDI pyBOP...)

19.04.2025 15:38

from :

TCDI or CDI

19.04.2025 15:27
15.04.2025 09:33

Isomerlab d.o.o.

 Naslov: Tržaška cesta 297 A , SI-1000 Ljubljana , Slovenia

 Phone: +386 40 764 332

 Email: info@isomerlab.com

Cookie - Analitics
They are used to record the website's obscurity analysis and provide us with data to provide a better user experience.
Cookie - social
Cookies required for plug-ins for sharing content from social media sites.
Cookie - chat
Cookies allow you to sign up, contact and communicate through the communication plug-in on the page.
Cookie - marketing
They target targeted advertising based on past user's activity on other sites.
What are cookies?
By visiting and using the site, you consent to the use and recording of cookies.OK Learn more about cookies